OptiNose
🇳🇴Norway
- Country
- 🇳🇴Norway
- Ownership
- Public
- Established
- 2000-01-01
- Employees
- 132
- Market Cap
- $155.3M
- Website
- http://www.optinose.com
- Introduction
OptiNose, Inc. operates as a pharmaceutical company. The firm engages in the development and commercialization of products for patients treated by ear, nose, throat, and allergy specialists. Its products include the XHANCE and ONZETRA Xsail. The company was founded by Per Gisle Djupesland and Helena Kyttari Djupesland in October 2000 and is headquartered in Yardley, PA.
Sarepta Seeks Accelerated Approval for DMD Gene Therapy SRP-9001
• Sarepta Therapeutics has submitted SRP-9001 (delandistrogene moxeparvovec) to the FDA for accelerated approval to treat ambulatory Duchenne muscular dystrophy (DMD) patients.
• The filing is based on positive data from early-stage studies, showing improvements in clinical function and a consistent safety profile, while awaiting Phase 3 EMBARK results.
• SRP-9001, a one-time gene therapy, delivers a shortened dystrophin gene via an AAV vector, addressing the underlying genetic defect in DMD patients.
• If approved, SRP-9001 would offer a one-time treatment option for DMD, contrasting with Sarepta's existing chronic exon-skipping therapies.
Nasal Polyposis: Emerging Therapies and Clinical Trial Updates
• Several companies are actively developing novel therapies for nasal polyposis, showing promising advancements in treatment options.
• Key players like GlaxoSmithKline, Sanofi, Regeneron, and AstraZeneca are progressing with therapies such as Fasenra, Tezepelumab and Dupixent.
• Phase 3 trial data for Tezspire (tezepelumab-ekko) demonstrated a significant reduction in nasal polyp size and nasal congestion.
• Biologics targeting inflammatory pathways are emerging as promising therapies for refractory cases of nasal polyposis.
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