UNIVERSITY OF TOYAMA

EURneffy, a needle-free adrenaline nasal spray, was approved in the EU and US as a first-of-its-kind treatment for anaphylaxis, overcoming barriers like fear of injections and accidental needle-related side effects. It offers comparable efficacy to traditional injectables, with simpler use and better temperature sensitivity, potentially increasing patient compliance.

JCOG1019 study compares watchful waiting to BCG therapy in high-grade T1 bladder cancer patients with no residual tumor post second TUR. Watchful waiting shows non-inferiority to BCG in relapse-free survival for T1 or deeper recurrence, with similar overall and metastasis-free survival. BCG has a slight advantage in intravesical recurrence-free survival. Watchful waiting may be a new standard for select patients, especially older or comorbid individuals, helping address BCG shortages and guide patient counseling. 90% of watchful waiting patients avoided BCG during follow-up.

Kobe University-led research finds low-dose aspirin or heparin treatment effective in preventing pregnancy loss or complications in women with self-targeting antibodies, with 87% live births in treated group vs. 50% in untreated, and complications reduced from 50% to 6%.

Watchful waiting is noninferior to intravesical BCG for high-grade pT1 bladder cancer without residual tumor at second TUR, with similar 5-year relapse-free, overall, and metastasis-free survival rates, but fewer adverse events.