UNIVERSITY OF TOYAMA

Aspirin and Heparin Combination Significantly Improves Live Birth Rates in Women with Recurrent Pregnancy Loss

8 months ago

• A Kobe University-led study reveals that low-dose aspirin or heparin treatment significantly increases live birth rates in women with recurrent pregnancy loss who test positive for specific self-targeting antibodies. • The research indicates that treatment with aspirin or heparin led to an 87% live birth rate, compared to 50% in untreated women, showcasing a substantial improvement in pregnancy outcomes. • The study also found that the treatment reduced pregnancy complications from 50% to 6% among live births, highlighting the potential of these drugs to improve maternal and fetal health. • Women with only the newly discovered antibodies who received the treatment had a 93% live birth rate with no pregnancy complications, suggesting a targeted and highly effective approach.

Watchful Waiting Shows Non-Inferiority to BCG in High-Grade T1 Bladder Cancer After Second TUR

8 months ago

• A phase 3 trial (JCOG1019) reveals watchful waiting is non-inferior to BCG for relapse-free survival in high-grade T1 bladder cancer patients with no residual tumor after a second TUR. • The study demonstrated similar overall survival and metastasis-free survival between the watchful waiting and BCG groups, suggesting comparable long-term outcomes. • Watchful waiting may reduce the need for BCG treatment in select patients, potentially alleviating BCG shortage issues and decreasing treatment-related adverse events. • Findings suggest watchful waiting could be a new standard of care for high-grade T1 bladder cancer patients with no residual tumor after a second TUR.