• A nationwide study in France found no increased risk of suicide or suicide attempts associated with GLP-1 receptor agonists (GLP-1 RAs).
• The research included patients with psychiatric disorders and obesity, addressing a gap in previous clinical trials.
• The study used a case-time-control design to account for confounding factors and exposure-trend bias, enhancing the reliability of the findings.
• Results showed a negative association between GLP-1 RA use and suicidal behaviors, suggesting short-term psychiatric safety.