39 million people live with HIV, 630,000 died in 2022, and 1.3 million acquired the disease. UNAIDS aims to end HIV/AIDS by 2030. Challenges include HIV's ability to integrate into host genomes, forming latent reservoirs, and global disparities in treatment access. Innovative strategies like Dr. Ho's nanomedicine targeting CCR5 and Nef aim to prevent and treat HIV. Dr. Mann's HIV-like particles (HLP) reactivate dormant HIV for cART and immune system targeting, moving towards clinical trials for a potential cure.