UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

PSMD Neuroimaging Marker Shows Promise in Identifying Dementia Risk

6 months ago

• A new neuroimaging marker, peak-width of skeletonized mean diffusivity (PSMD), correlates with general cognition and may identify individuals at risk of dementia. • The study found that higher PSMD values were associated with lower general cognitive function, independent of age, sex, education and intracranial volume. • PSMD demonstrates excellent instrumental properties and biological validation, making it a potential biomarker for clinical trials related to vascular contributions to cognitive impairment and dementia (VCID). • Researchers suggest PSMD's non-invasive, automated, and reliable nature makes it ideal for assessing cerebral small vessel diseases in dementia studies.