• A single 800 mg dose of CBD significantly reduced alcohol cravings in individuals with alcohol use disorder (AUD).
• The ICONIC trial demonstrated that CBD lowered activity in the nucleus accumbens (NAc), the brain's reward center.
• Higher CBD blood levels correlated with reduced cravings and decreased NAc activation, suggesting a dose-dependent effect.
• The study provides initial clinical evidence supporting CBD as a potential treatment for AUD by targeting craving and reward pathways.