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Central Institute of Mental Health

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CBD Reduces Alcohol Cravings and Brain Reward Center Activity in AUD Patients

• A single 800 mg dose of CBD significantly reduced alcohol cravings in individuals with alcohol use disorder (AUD). • The ICONIC trial demonstrated that CBD lowered activity in the nucleus accumbens (NAc), the brain's reward center. • Higher CBD blood levels correlated with reduced cravings and decreased NAc activation, suggesting a dose-dependent effect. • The study provides initial clinical evidence supporting CBD as a potential treatment for AUD by targeting craving and reward pathways.
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