The Jackson Laboratory

NIH-Funded Teams Develop Precision Gene Delivery Systems for Neural Cells

3 days ago

• Research teams funded by the NIH have created a versatile toolkit of gene delivery systems that can target specific neural cell types in the human brain and spinal cord with unprecedented precision. • The new delivery platform uses modified adeno-associated viruses (AAVs) to transport genetic material into targeted cells, potentially transforming how scientists study neural circuits without requiring genetically modified animals. • This breakthrough could accelerate the development of precise gene therapies for neurological disorders like ALS, Alzheimer's, and Parkinson's disease by targeting only affected cells rather than merely treating symptoms.

Novel BTK-BCL2 Inhibitor Combination Shows Promise Against Drug-Resistant DLBCL with BCL10 Mutations

4 months ago

A groundbreaking study reveals that combining BTK inhibitor pirtobrutinib with BCL2 inhibitor venetoclax effectively overcomes drug resistance in diffuse large B-cell lymphoma (DLBCL) with BCL10 mutations. The research demonstrates that while BCL10 mutations drive resistance to both drugs individually, the combination therapy leads to complete tumor regression in preclinical models, suggesting a promising new treatment strategy for this aggressive lymphoma subtype.