NATIONAL INSTITUTES OF HEALTH

NIH researchers developed TrialGPT, an AI algorithm that efficiently matches potential volunteers to relevant clinical trials on ClinicalTrials.gov, potentially enhancing clinical trial enrollment and medical research advancements.

NIH researchers developed TrialGPT, an AI model derived from ChatGPT, to streamline clinical trial volunteer recruitment, reducing time and maintaining accuracy. Published in Nature Communications, it aims to address the 80% failure rate in timely patient recruitment, particularly in cancer trials. TrialGPT matches patients to trials with near-human accuracy, saving clinicians 40% screening time.

NIH researchers developed TrialGPT, an AI algorithm to match potential volunteers to relevant clinical trials on ClinicalTrials.gov, enhancing trial enrollment efficiency and accuracy. The tool uses large language models to process patient summaries and identify eligible trials, reducing clinician screening time by 40% while maintaining accuracy. Selected for The Director's Challenge Innovation Award, TrialGPT aims to improve clinical trial recruitment and reduce participation barriers.

NIH's $50.1 billion FY25 budget focuses on cancer research, neuroscience, precision medicine, AI, and cybersecurity, aiming to drive healthcare advancements and improve patient outcomes.

Semaglutide, top-selling drug in 2023 with $13.8 billion in sales, is estimated to be eligible for 136.8 million US adults, based on NHANES data from 2015-2020. Eligibility criteria include diabetes, weight management, and secondary prevention of CVD. This highlights potential impact on pharmaceutical spending and urgent need for cost-reducing interventions.

UH Mānoa’s JABSOM receives $500,000 from NIH for ethical AI development in public health, expanding the ARCH Collaborative’s AI Resource Concierge for Healthcare to reduce disparities in underserved communities.

Bolder BioTechnology announced NIAID's option to fund the second year of Contract NIH-BAA-75N93023C00011, focusing on BBT-059's advanced development as a radiation medical countermeasure. The contract aims to complete GMP manufacturing, preclinical safety studies, and enable an Investigational New Drug Application filing with the FDA, totaling $3,079,369.

UC Cancer Center receives $2.3M NCI grant to develop a novel technique using PET scans to visualize genetically modified immune cells in cancer patients, aiming to improve CAR T-cell therapy for solid tumors.

NIH developed AI algorithm TrialGPT matches potential volunteers to relevant clinical trials on ClinicalTrials.gov, improving enrollment efficiency and accuracy. TrialGPT processes patient summaries, identifies eligible trials, and explains eligibility criteria, saving clinicians 40% screening time. Selected for Director's Challenge Innovation Award to further assess real-world performance.