NATIONAL INSTITUTES OF HEALTH

NATIONAL INSTITUTES OF HEALTH logo
🇺🇸United States
Ownership
Subsidiary, Private
Established
1948-01-01
Employees
1K
Market Cap
-
Website
http://www.nidcr.nih.gov
drugs.com
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Ozempic or Saxenda for Weight Loss: Which Works Best?

Ozempic and Wegovy (semaglutide) outperformed Saxenda (liraglutide) in weight loss, with 61% of obese and 23% of diabetic patients losing 10%+ body weight after a year. Saxenda achieved similar results in only 29% of obese and 12% of diabetic patients. Semaglutide users were more likely to lose 10%+ weight if treated for obesity, adhered to the drug schedule, had a higher BMI, and were female. Higher doses produced more weight loss.
upm.edu.ph
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[INVITATION] 1st Annual Clinical Trials and Translational Science Meeting this September

Join the 1st Annual Clinical Trials and Translational Science Meeting on September 24-27, 2024, organized by NCTTC and NCGM, supported by AMED, and in collaboration with HERC, Oxford Population Health. The event aims to strengthen clinical trial capacities and establish partnerships, with registration available at bit.ly/nihncttcreg.
medicine.wustl.edu
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Huang named head of pathology & immunology

Eric J. Huang, MD, PhD, a neurodevelopmental and neurodegenerative diseases expert, will head the Department of Pathology & Immunology at Washington University School of Medicine in St. Louis starting Jan. 1.

Association of Statin, Metformin, and Aspirin Use with Hepatocellular Carcinoma

Lipophilic statins reduce HCC risk; hydrophilic statins, aspirin, and metformin do not. A clinical trial (NCT05028829) is ongoing to confirm benefits of atorvastatin.
hub.jhu.edu
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Reimagining alternatives to animal testing

Aristotle's early animal dissections evolved into standard drug development practices by the late 1930s, leading to the 1938 Federal Food, Drug, and Cosmetic Act. Despite animal testing's contributions to medicine, 95% of drugs fail post-testing. Thomas Hartung's research at Johns Hopkins Center for Alternatives to Animal Testing advocates for AI and organoid cultures to replace animal tests, with some success. The FDA Modernization Act of 2023 no longer requires animal testing before clinical trials, and collaborations like CAAT's with the FDA aim to advance nonanimal testing methods. However, challenges remain in replacing animal models entirely due to technological limitations and systemic resistance.
morningstar.com
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Spark Biomedical Awarded National Institute on Drug Abuse Funding to Develop AI

Spark Biomedical partners with Battelle and Hazelden Betty Ford to develop an AI algorithm for detecting opioid withdrawal symptoms and cravings, funded by a $318,875 SBIR grant from NIDA. Phase I focuses on data collection and AI algorithm development, while Phase II aims to integrate the algorithm with Spark's FDA-cleared tAN® device, Sparrow® Ascent, for closed-loop neurostimulation treatment.
pharmexec.com
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FDA Approves Tremfya for Moderately to Severely Active Ulcerative Colitis

The FDA approved Johnson & Johnson’s Tremfya for treating adults with moderately to severely active ulcerative colitis, marking the first fully-human, dual-acting monoclonal antibody targeting IL-23 and CD64. Tremfya showed significant clinical and endoscopic improvements, with 50% and 45% of patients achieving clinical remission at 200 mg and 100 mg doses, respectively, compared to 19% in the placebo group. Common adverse events included respiratory tract infections, injection site reactions, and arthralgia.
bcm.edu
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Tumor-induced B cell changes reveal potential biomarker for treatment response in triple negative breast cancer

Researchers at Baylor College of Medicine identified two B cell abnormalities in triple negative breast cancer patients, which could serve as blood biomarkers for predicting response to chemotherapy and immunotherapy. TiBA-0 patients showed no B cell changes, while TiBA-1 and TiBA-2 exhibited reduced and immature B cells, respectively, leading to poorer treatment responses. These systemic immune changes can be detected via a blood draw, potentially aiding in patient stratification for tailored treatments.
vcuhealth.org
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How one Virginia hospital is icing out ALS

The ALS Bucket Challenge, now 10 years old, continues to raise awareness and funds for ALS research. The VCU Health ALS Clinic, the largest in Virginia, has tripled in size and is involved in major research studies. Since the challenge, three FDA-approved medications for ALS have been developed, and awareness has significantly increased. The clinic's care plan includes multidisciplinary care, access to therapies, and clinical research. The VCU Health ALS Clinic aims to expand its research and diagnostic programs, continuing the fight until a cure is found.
silicon.co.uk
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Sinopia Secures Phase II SBIR Grant from the National Institute of Dental and Craniofacial

Sinopia Biosciences awarded $2.2M Phase II SBIR grant from NIDCR to advance oral mucositis program using LEADS® platform, combining AI/ML and high-throughput screening for therapeutic target identification.
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