Katholieke Universiteit te Leuven

10x Genomics launches two new Chromium products, GEM-X Flex and GEM-X Universal Multiplex, to democratize single cell analysis with improved performance, workflow, and cost-effectiveness.

A study reveals MX2 protein assembles structures in cells to lure and trap HIV-1 and herpes simplex virus-1, mimicking nuclear pore complexes to prevent viral spread.

Researchers discovered MX protein assembles decoy structures mimicking nuclear pores, trapping or puncturing HIV-1 and herpes simplex virus-1, preventing viral spread.

Researchers at VIB-UGent Center for Medical Biotechnology discovered MX protein assembles virus decoy structures mimicking nuclear pore complexes, trapping or puncturing HIV-1 and herpes simplex virus-1, potentially leading to new antiviral therapies.

Adcendo's ADCE-D01, an ADC targeting uPARAP in mesenchymal cancers, received FDA IND clearance for Phase I/II ADCElerate-01 trial in metastatic/unresectable STS. The study aims to assess ADCE-D01's safety, pharmacokinetics, and efficacy.

The TRIPOD+AI update provides harmonised guidance for reporting prediction model studies, superseding TRIPOD 2015, to accommodate AI and machine learning methods. The new 27-item checklist aims for complete, accurate, and transparent reporting, facilitating study appraisal and model implementation.

The article updates guidelines for managing hyperglycemia in type 2 diabetes, emphasizing a holistic approach including weight management, physical activity, and social determinants of health. It highlights the benefits of SGLT2 inhibitors and GLP-1 receptor agonists for cardiorenal protection, advocating for personalized, person-centered care and the importance of diabetes self-management education and support.

The ESHG 2017 conference celebrated its 50th anniversary, highlighting advancements in human genetics. Key topics included reproductive genetics, prenatal diagnostics, and the impact of genetic variations on fertility and pregnancy outcomes. Studies presented explored the role of CNVs in recurrent pregnancy loss, novel genetic screening methods for male infertility, and the identification of new disease genes for conditions like primary ovarian insufficiency. Non-invasive prenatal testing (NIPT) for detecting chromosomal abnormalities and the application of expanded carrier screening for recessive disorders were also discussed, emphasizing the importance of early intervention and genetic counseling.