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Puretech Health

Puretech Health logo
🇺🇸United States
Ownership
Public
Established
2001-01-01
Employees
90
Market Cap
$598.2M
Website
https://puretechhealth.com
Introduction

PureTech Health Plc engages in the provision of differentiated medicines for devastating diseases, including inflammatory, fibrotic and immunological conditions, intractable cancers, lymphatic and gastrointestinal diseases and neurological and neuropsychological disorders. It operates through the following segments: Internal, Controlled Founded Entities, Non-Controlled Founded Entities, and Parent Company and Others. The Internal segment focuses on immunological, fibrotic, and lymphatic system mechanisms. The Controlled Founded Entities segment is composed of the group’s subsidiaries that are currently consolidated operational subsidiaries that either have or have plans to hire independent management teams and currently have already raised, or are currently in the process of raising, third-party dilutive capital. The Non-Controlled Founded Entities segment includes companies wherein the group no longer holds majority voting control as a shareholder and no longer has the right to elect a majority of the members of the subsidiaries’ Board of Directors. The Parent Company and Other segment represents activities that are not directly attributable to the operating segments, such as the activities of the parent, corporate support functions and certain research and development support functions that are not directly attributable to a strategic business segment as well as the elimination of intercompany transactions. The company was founded by Robert S. Langer Jr., Bennett M. Shapiro, and Daphne Zohar on May 8, 2015 and is headquartered in Boston, MA.

Study to Determine Potential for Drug-drug Interactions When Co-administering Deupirfenidone (LYT-100) and Nintedanib

Phase 1
Not yet recruiting
Conditions
Drug Interactions
Interventions
First Posted Date
2024-12-04
Last Posted Date
2024-12-04
Lead Sponsor
PureTech
Target Recruit Count
30
Registration Number
NCT06717100

A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS)

Phase 1
Recruiting
Conditions
AML, Adult Recurrent
MDS
Interventions
First Posted Date
2023-04-25
Last Posted Date
2025-05-28
Lead Sponsor
PureTech
Target Recruit Count
90
Registration Number
NCT05829226
Locations
🇺🇸

Mass. General Hospital-Harvard, Boston, Massachusetts, United States

🇺🇸

Virginia Commonwealth University Medical Center, Richmond, Virginia, United States

🇺🇸

Baptist Health South Florida-Miami Cancer Institute, Miami, Florida, United States

and more 6 locations

LYT-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Phase 2
Active, not recruiting
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
First Posted Date
2022-04-11
Last Posted Date
2025-05-06
Lead Sponsor
PureTech
Target Recruit Count
240
Registration Number
NCT05321420
Locations
🇦🇷

Respira Salud Clinica Integral, Godoy Cruz, Argentina

🇦🇷

Instituto Ave Pulmo - Fundacion Enfisema, Mar Del Plata, Argentina

🇦🇷

Polo de Salud Vistalba, Mendoza, Argentina

and more 100 locations

LYT-300 in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Other: Placebo
First Posted Date
2021-11-22
Last Posted Date
2023-11-13
Lead Sponsor
PureTech
Target Recruit Count
186
Registration Number
NCT05129865
Locations
🇦🇺

CMAX, Adelaide, South Australia, Australia

LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors

Phase 1
Completed
Conditions
Metastatic Cancer
Solid Tumor
Urothelial Carcinoma
Head and Neck Cancer
Colorectal Cancer
Pancreatic Cancer
Interventions
Drug: Gemcitabine/nab-paclitaxel
First Posted Date
2020-12-14
Last Posted Date
2025-02-12
Lead Sponsor
PureTech
Target Recruit Count
44
Registration Number
NCT04666688
Locations
🇺🇸

UCLA, Los Angeles, California, United States

🇺🇸

University of Colorado Hospital, Denver, Colorado, United States

🇺🇸

Sarah Cannon Research Institute at Health One, Denver, Colorado, United States

and more 8 locations

LYT-100 in Post-acute COVID-19 Respiratory Disease

Phase 2
Terminated
Conditions
Post-acute COVID-19 Respiratory Disease
Covid19
Interventions
Other: Placebo
First Posted Date
2020-12-03
Last Posted Date
2024-02-14
Lead Sponsor
PureTech
Target Recruit Count
185
Registration Number
NCT04652518
Locations
🇺🇸

University of Southern California - Keck School of Medicine, Los Angeles, California, United States

🇺🇸

Center for Advanced Research and Education, Gainesville, Georgia, United States

🇺🇸

GenHarp Clinical Solutions, Evergreen Park, Illinois, United States

and more 28 locations

LYT-100 in Patients With BCRL

Phase 2
Terminated
Conditions
Lymphoedema
Breast Cancer Related Lymphoedema
Interventions
Drug: LYT-100 BCRL
Drug: Placebo BCRL
First Posted Date
2020-01-28
Last Posted Date
2024-04-23
Lead Sponsor
PureTech
Target Recruit Count
50
Registration Number
NCT04243837
Locations
🇺🇸

MACRO Trials, Los Angeles, California, United States

🇺🇸

Accel Research Network, Atlanta, Georgia, United States

🇦🇺

Macquarie University Health Sciences Centre, Sydney, Australia

and more 4 locations
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