Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat
- Conditions
- Sickle Cell DiseaseHemolytic Anemia
- Interventions
- First Posted Date
- 2020-11-02
- Last Posted Date
- 2025-05-11
- Target Recruit Count
- 15
- Registration Number
- NCT04610866
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)
- Conditions
- CardiomyopathyObstructive Hypertrophic Cardiomyopathy
- First Posted Date
- 2020-10-27
- Last Posted Date
- 2022-06-01
- Target Recruit Count
- 325
- Registration Number
- NCT04603521
- Locations
- 🇺🇸
National Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland, United States
Fostamatinib for Hospitalized Adults With COVID-19
- First Posted Date
- 2020-10-08
- Last Posted Date
- 2022-03-02
- Target Recruit Count
- 59
- Registration Number
- NCT04579393
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
🇺🇸INOVA Health Systems, Falls Church, Virginia, United States
COV2Base-A Rare Disease by COVID Study
- Conditions
- Chronic Health ConditionsOlder Age is Associated With Increased Pathogenicity
- First Posted Date
- 2020-09-25
- Last Posted Date
- 2023-01-20
- Target Recruit Count
- 1748
- Registration Number
- NCT04564274
- Locations
- 🇺🇸
National Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland, United States
Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease
- First Posted Date
- 2020-08-17
- Last Posted Date
- 2024-01-02
- Target Recruit Count
- 46
- Registration Number
- NCT04514510
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Red Cell Half Life Determination in Patients With and Without Sickle Cell Disease
- Conditions
- Sickle Cell DiseaseSickle Cell Anemia
- Interventions
- First Posted Date
- 2020-07-20
- Last Posted Date
- 2024-02-13
- Target Recruit Count
- 22
- Registration Number
- NCT04476277
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors
- Conditions
- Hematologic DiseasesWide Spectrum of Diseases
- First Posted Date
- 2020-06-30
- Last Posted Date
- 2025-05-20
- Target Recruit Count
- 10000
- Registration Number
- NCT04450927
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7 Abnormalities After Immunosuppressive Therapy
- Conditions
- Severe Aplastic Anemia
- First Posted Date
- 2020-06-18
- Last Posted Date
- 2022-09-29
- Target Recruit Count
- 38
- Registration Number
- NCT04436367
- Locations
- 🇺🇸
National Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland, United States
Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy
- Conditions
- Severe Aplastic Anemia
- First Posted Date
- 2020-06-18
- Last Posted Date
- 2023-03-16
- Target Recruit Count
- 173
- Registration Number
- NCT04436380
- Locations
- 🇺🇸
National Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland, United States
Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait
- Conditions
- Hypercoagulable StateSickle Cell DiseaseSickle Cell TraitVenous ThrombosisVenous Thromboembolism
- First Posted Date
- 2020-04-16
- Last Posted Date
- 2025-04-24
- Target Recruit Count
- 119
- Registration Number
- NCT04349189
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States