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National Heart, Lung, and Blood Institute

🇺🇸United States

Country: 🇺🇸United States

Ownership: -

Employees: -

Market Cap: -

Website

Clinical Trials

Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait

Completed

Conditions: Hypercoagulable State
Sickle Cell Disease
Sickle Cell Trait
Venous Thrombosis
Venous Thromboembolism

First Posted Date: 2020-04-16

Last Posted Date: 2025-04-24

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 119

Registration Number: NCT04349189

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Phase 2

Recruiting

Conditions: Severe Aplastic Anemia

Interventions: Drug: Eltrombopag
Drug: Cyclosporine
Drug: Horse-Anti-thymocyte-Globulin

First Posted Date: 2020-03-11

Last Posted Date: 2025-06-22

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 80

Registration Number: NCT04304820

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis

Not Applicable

Completed

Conditions: Obesity
Cardiometabolic Diseases
Atherosclerotic Cardiovascular Disease
Dyslipidemia
Psoriasis

First Posted Date: 2020-02-17

Last Posted Date: 2023-12-27

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 29

Registration Number: NCT04271735

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag

Phase 1

Completed

Conditions: Anemia, Diamond-Blackfan

Interventions: Drug: Eltrombopag

First Posted Date: 2020-02-17

Last Posted Date: 2025-04-27

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 15

Registration Number: NCT04269889

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers

Phase 1

Recruiting

Conditions: Cardiovascular Disease

Interventions: Biological: Fx-5A peptide complex

First Posted Date: 2020-01-02

Last Posted Date: 2025-07-01

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 64

Registration Number: NCT04216342

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Phase 2

Terminated

Conditions: Chronic Lymphocytic Leukemia (CLL)
Small Lymphocytic Leukemia (SLL)

Interventions: Drug: Duvelisib
Drug: Ibrutinib

First Posted Date: 2019-12-24

Last Posted Date: 2022-03-09

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 3

Registration Number: NCT04209621

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

CHIP/CCUS Natural History Protocol

Recruiting

Conditions: Clonal Cytopenia of Undetermined Significance
Clonal Hematopoiesis of Indeterminate Potential

First Posted Date: 2019-09-25

Last Posted Date: 2025-05-01

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 306

Registration Number: NCT04102423

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women

Recruiting

Conditions: Cardiovascular (CV) Risk

First Posted Date: 2019-07-10

Last Posted Date: 2025-06-13

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 250

Registration Number: NCT04014348

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

Phase 1

Recruiting

Conditions: Myeloid Chimerism

First Posted Date: 2019-07-05

Last Posted Date: 2025-05-25

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 32

Registration Number: NCT04008368

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

Phase 2

Recruiting

Conditions: Chronic Lymphocytic Leukemia

Interventions: Drug: During Venetoclax

First Posted Date: 2019-06-14

Last Posted Date: 2025-06-03

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 75

Registration Number: NCT03986034

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

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