Aetion, Inc. | MedPath

Real-World Data Emulation Study Challenges Clinical Trial Findings on Apixaban and Warfarin

9 months ago

• Researchers emulated a clinical trial using real-world data to compare apixaban and warfarin for stroke prevention in atrial fibrillation patients. • The emulation study found similar outcomes for both drugs, differing from the original trial that favored apixaban. • Discrepancies may stem from better warfarin control, suboptimal apixaban dosing, and differences in patient ethnicity and concomitant medication use. • The approach could help assess treatment effects in underrepresented groups and validate trial results in real-world settings.