• The Veterans Affairs (VA) Health Care System is utilizing a clinical trial network to study metastasis-directed therapy for veterans with oligometastatic prostate cancer (OMPC).
• Challenges in timely site activation were addressed through project management strategies to maximize efficiency in the study start-up process.
• The trial protocol was amended to include de novo OMPC patients and expand the allowed metastases from five to ten, adapting to evolving clinical paradigms.
• Initiatives were developed to maintain local study team engagement, fostering collaboration and adding value to the overall clinical program through study participation.