First Affiliated Hospital Of Fujian Medical University

Researchers used spatial proteomics to analyze skin samples from toxic epidermal necrolysis patients, identifying hyperactivation of the JAK/STAT pathway. JAK inhibitors, administered to seven patients, led to rapid improvement and full recovery. This study suggests potential for JAK inhibitors in treating the condition and highlights the impact of spatial proteomics in medical breakthroughs.

Researchers led by Matthias Mann identified the JAK/STAT pathway as the main driver of toxic epidermal necrolysis (TEN) using spatial proteomics, leading to successful treatment with JAK inhibitors in seven patients, marking a significant breakthrough in treating this deadly skin reaction.