KEIO UNIVERSITY

Adipose-Derived Stem Cell Injections Show Promise in Treating Inflammatory Eye Diseases

3 months ago

• Japanese researchers demonstrate that local injections of adipose-derived mesenchymal stem cells effectively reduce inflammation in ocular graft-versus-host disease, offering a safer alternative to corticosteroids. • The study reveals that stem cell treatment increases regulatory T cells and enhances tissue healing, with injected cells naturally clearing within a week, minimizing long-term complications. • Researchers at Fujita Health University report successful localized therapy effects in mouse models, setting the stage for potential human clinical trials of this targeted treatment approach.

Cell Therapy for Heart Failure Shows Promise Despite Long Development Road

6 months ago

• A new review highlights the potential of cell-based therapies for heart failure, which accounts for 13% of global deaths, noting that half of patients die within five years. • The review analyzes 20 years of clinical trials, revealing that while no cell therapies have gained approval, they have demonstrated safety and some beneficial effects. • Ongoing trials are exploring new cell types like pluripotent stem cell-derived cardiomyocytes and novel cell-free products to refine cell therapy's role in heart failure treatment. • Researchers emphasize the importance of addressing criticisms through rigorously designed and adequately powered trials to ensure continued progress in cell therapy research.