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villagereport.ca
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Family doc says profession endangered until province antes up better pay

Dr. Matthew Ladda, a new family doctor in Collingwood, has quickly filled his roster with 450 patients from local wait lists. He faces significant work to catch up patients who have been unattached for years, reviewing thousands of pages of old records. Ladda, who grew up in New Brunswick and trained at the University of Toronto, is committed to providing care in Collingwood for at least five years. Municipalities in South Georgian Bay are investing in physician recruitment to address the ongoing crisis in family medicine, with an estimated 6,000-7,000 people in the region lacking a local family doctor.
barrietoday.com
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New local doctor says profession endangered until province antes up better pay

Dr. Matthew Ladda, a new family doctor in Collingwood, has quickly filled his roster with 450 patients from local wait lists. He faces significant challenges in catching up with their long-overdue care, including reviewing thousands of pages of old records. Ladda's practice attracts patients from beyond Collingwood due to the family medicine crisis, and he has not turned away prospective patients outside town boundaries. Municipalities in southern Georgian Bay are investing in physician recruitment to address the shortage, with Collingwood offering incentives and joining a plea to the province to fix the doctor shortage.
jci.org
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Hidradenitis suppurativa: key insights into treatment success and failure

Hidradenitis suppurativa (HS) treatment insights highlight B cells, fibroblasts, and bacterial triggers as central to inflammation and fibrosis, with recent trials showing varying success rates for therapies targeting these elements, necessitating further research to understand HS pathogenesis and optimize treatment responses.
aacr.org
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Early Detection and Prevention: Stopping Cancer in its Tracks

AACR focuses on cancer prevention and early detection, with Kornelia Polyak's pioneering research highlighting the importance of early-stage disease study. The AACR established the Cancer Prevention Working Group in 2021 to support innovative science and public education. Liquid biopsies and multi-cancer early detection (MCED) tests are being developed to improve screening. The NCI's National Cancer Plan and President Biden's proclamation of April 2024 as National Cancer Prevention and Early Detection Month emphasize the urgency of these efforts. Researchers are exploring liquid biopsies, MCED, cancer interception, and population science to advance early detection and prevention strategies.
drugtargetreview.com
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INPP4B exerts its tumour-promoting effects via lysosomes

INPP4B, along with PIKfyve and TRPML-1, drives pancreatic cancer metastasis by moving lysosomes to the cell periphery, degrading extracellular support structures, and facilitating cell migration.
canadiandimension.com
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Democratic breakdown or breakthrough?

Corporate capitalism's profit obsession drives environmental disasters and economic disparities, eroding trust in governments. Despite public support for renewable energy and progressive taxation, policies remain inadequate. Upcoming elections in the US and Canada may further democratic breakdown, necessitating urgent action for a democratic electoral breakthrough. Activists and voters must recognize the readiness for social issue-based platforms, while well-organized progressive movements can drive change.
hcplive.com
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Depagliflozin Lowers Risk of Decline in Late-Stage Kidney Disease

Dapagliflozin reduced eGFR decline and kidney events in advanced CKD patients, with lower risks of renal replacement therapy and cardiovascular outcomes. It also improved kidney function and glycemic control in youth with type 1 diabetes, though with increased ketone events.

Robotic System Flags Potential Arrhythmia Therapies

A robotic system microinjects heart cells between beats to assess gap junction function, identifying a compound that reduces heartbeat irregularities in a mouse model of arrhythmogenic cardiomyopathy (ACM), a leading cause of sudden cardiac death among young adults.
itif.org
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Evidence-Based Biopharmaceutical Policymaking: Symposium Report

ITIF convened a symposium on assessing financial returns from biopharmaceutical clinical development, discussing investor behavior, drug development evolution, and policy implications. The symposium highlighted the impact of the Inflation Reduction Act on investment patterns, particularly in early-stage biopharmaceutical companies, and the challenges posed by price controls. ITIF announced a grant program awarding $50,000 each to three researchers to support better evidence on drug development returns, with submissions considered for publication in 'Health Affairs Scholar'.
finance.yahoo.com
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New Analysis of Phase 3 Data Demonstrating Renal Protective Benefits of Sotagliflozin

Lexicon Pharmaceuticals announced a new analysis of its Phase 3 SCORED trial showing sotagliflozin's protective effects in diabetic kidney disease (DKD) patients, to be presented at Kidney Week 2024.
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