New companies aim to challenge Eli Lilly and Novo Nordisk's dominance in the GLP-1 weight-loss drug market, projected to reach $200 billion by 2031. Emerging competitors like Roche, Amgen, Pfizer, and AstraZeneca focus on enhanced efficacy and convenience to disrupt the market. By 2029, 16 new drugs are expected to enter the market, adding $70 billion to the segment. Despite pricing challenges and limited international penetration, GLP-1 drugs are expected to see significant usage in the U.S., with Novo and Lilly maintaining a strong market presence through pipeline advancements.