• A culturally adapted Cognitive Behavioral Therapy (CBT) manual was developed in Bengali for treating major depression in Bangladesh.
• The adaptation process involved gathering information, expert evaluations, and pilot testing to ensure cultural relevance and effectiveness.
• Preliminary results from a pilot study with five participants showed the adapted CBT is functionally feasible for wider use.
• The adapted CBT integrates local metaphors, religious practices, and respects hierarchical roles to enhance patient engagement and outcomes.