The Multiple Myeloma Research Foundation (MMRF) has enrolled the first patient in the Horizon Clinical Trials Program, an adaptive platform trial across the Multiple Myeloma Research Consortium (MMRC). The trial aims to determine the best combination, sequence, and duration of therapy for patients with relapsed and refractory myeloma. The first arm will evaluate dosing approaches with Tecvayli (teclistamab), manufactured by Johnson & Johnson.