UNIVERSITY AT BUFFALO

University at Buffalo researchers have developed a lipidated peptide molecule that provides chronic pain relief for up to three weeks with a single local injection, targeting the Magi-1/NaV1.8 protein interaction.

A recent study published in JAMA Network Open reveals that maternal obesity, gestational diabetes, and hypertensive disorders during pregnancy are associated with elevated blood pressure in offspring.

A new observational study found that people with diabetes taking GLP-1 drugs had more than twice the risk of developing neovascular age-related macular degeneration compared to those not taking the medications, with risk increasing from 0.1% to 0.2% after one year.

Exposure to air pollution during pregnancy, particularly in the final month, increases newborn risk of requiring intensive care treatment by up to 35%, according to recent research published in Scientific Reports.

• Octave Bioscience's Multiple Sclerosis Disease Activity (MSDA) Test has demonstrated significant impact on clinical decision-making, influencing nearly 60% of MS management cases in a real-world study. • The multi-protein biomarker assay, which measures 18 proteins to assess MS disease activity, has received New York State CLEP certification, making it available in all 50 states. • Study findings show the MSDA Test provides objective data that supports treatment decisions, with nearly 1 in 5 test results leading clinicians to adjust MS management strategies.

• Real-world data presented at AUA 2025 shows the CVAC System achieves significant kidney stone volume reduction of up to 99% in most patients, with one study reporting a median clearance rate of 96.4%. • The CVAC System demonstrated superior performance compared to flexible and navigable ureteric access sheath (FANS), removing significantly more absolute stone volume while maintaining consistently low intrarenal pressure. • Multiple studies using Quantitative Stone Analysis Software (QSAS) validate stone volume as a more precise and clinically meaningful measure for assessing kidney stone treatment outcomes.

Research presented at AHA 2024 Scientific Sessions demonstrates that both historical redlining and current structural racism significantly decrease life expectancy, particularly affecting minority populations.

The University at Buffalo (UB) has inaugurated the FOXG1 Research Center (FRC) to focus on developing treatments for FOXG1 syndrome and related neurodevelopmental disorders.