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Lack of Approved Therapies Highlights Challenges in Vaping Cessation

• E-cigarettes, initially seen as a smoking cessation tool, have led to a new wave of nicotine addiction, with many users finding it difficult to quit vaping. • The FDA has not approved e-cigarettes for smoking cessation, and there is a lack of data on effective methods to stop vaping, creating a significant unmet need. • Achieve Life Sciences is developing cytisinicline, a potential first-in-class medication for vaping cessation, which has received Breakthrough Therapy designation from the FDA. • Alternative methods like nicotine pouches are being used to wean off vaping, but experts advise a short-term approach to avoid prolonged nicotine dependence.
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