Blinatumomab, a bispecific T-cell engager, combined with chemotherapy significantly improves three-year disease-free survival rates in pediatric B-cell acute lymphoblastic leukemia patients, according to the AALL1731 study. The study found a 96% DFS rate with the combination therapy versus 87.9% with chemotherapy alone. Despite rare but serious side effects and high costs, the FDA's approval of blinatumomab for pediatric patients offers hope for improved treatment outcomes.