Associated Capital
🇺🇸United States
- Country
- 🇺🇸United States
- Ownership
- -
- Employees
- 25
- Market Cap
- -
- Introduction
Air Canada is Canada's largest airline, serving nearly 50 million passengers each year together with its low-cost sub-brand called Rouge and contracts for regional connection flights to its network. Air Canada is a sixth-freedom airline, which flies many US-based passengers on long-haul trips with a layover in Canada.
AC Immune's Parkinson's Immunotherapy Shows Promising Results in Phase 2 Trial
• ACI-7104.056 active immunotherapy demonstrated strong immunogenicity in early Parkinson's disease patients, producing anti-alpha-synuclein antibody levels 20-fold higher than placebo after four immunizations.
• The Phase 2 VacSYn trial showed repeated immunizations successfully amplified antibody response, with no serious adverse events reported and only mild injection site reactions and headaches as common side effects.
• AC Immune may expand the trial to include 150 additional patients later in 2025, with plans to evaluate disease progression markers and establish proof-of-concept for this potential first-in-class treatment approach.
Retifanlimab Plus Chemotherapy Shows Promise in Advanced Squamous Cell Anal Carcinoma
• Phase 3 POD1UM-303 trial shows retifanlimab combined with chemotherapy significantly improves progression-free survival in patients with locally recurrent or metastatic squamous cell anal carcinoma (SCAC).
• The combination therapy demonstrated a median PFS of 9.3 months compared to 7.4 months with chemotherapy alone, marking a potential new standard of care.
• Interim overall survival data also suggest a trend towards improvement with the addition of retifanlimab, with manageable immune-related adverse effects.
• The study's success supports a planned supplemental biologics license application (sBLA) for retifanlimab, offering hope for addressing unmet needs in SCAC treatment.
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