INDIAN INSTITUTE OF TECHNOLOGY MADRAS

Extended Time Window for Alteplase Shows Breakthrough Results in Late-Stage Stroke Treatment

3 months ago

• A groundbreaking study reveals alteplase improves stroke recovery by 54% when administered up to 24 hours after symptom onset, dramatically extending the current 4.5-hour treatment window. • Advanced CT perfusion imaging enabled identification of salvageable brain tissue in patients, with 40% of alteplase-treated participants showing minimal to no disability after 90 days. • Despite a slightly increased risk of brain bleeding (3.8% vs 0.5%), the study demonstrates comparable mortality rates between treatment groups, suggesting a manageable safety profile.