Dupixent reduced COPD exacerbations and improved lung function in adults with type 2 inflammation, according to BOREAS and NOTUS phase 3 studies. Dupixent was approved by the European Medicines Agency as an add-on treatment for uncontrolled COPD patients on maximal inhaled therapy. The pooled analysis showed a 31% reduction in exacerbations and a 147 mL improvement in lung function compared to placebo, with safety consistent with known profiles.