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CSL Behring

🇧🇪Belgium

Country: 🇧🇪Belgium

Ownership: -

Employees: -

Market Cap: -

Website: http://www.cslbehring.com/

Clinical Trials

An Observational Cohort Study to Characterize the Effectiveness and Safety of HEMGENIX® in Patients With Hemophilia B

Recruiting

Conditions: Hemophilia B

Interventions: Biological: Factor IX (FIX)
Genetic: HEMGENIX

First Posted Date: 2023-08-24

Last Posted Date: 2024-12-06

Lead Sponsor: CSL Behring

Target Recruit Count: 500

Registration Number: NCT06008938

Locations: 🇺🇸
American Thrombosis and Hemostasis Network, Rochester, New York, United States

Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy in Adults with Hemophilia B with Pretreatment AAV5 Neutralizing Antibodies.

Phase 3

Not yet recruiting

Conditions: Hemophilia B

Interventions: Genetic: CSL222 (AAV5-hFIXco-Padua)

First Posted Date: 2025-01-27

Last Posted Date: 2025-03-05

Lead Sponsor: CSL Behring LLC

Target Recruit Count: 2

Registration Number: 2023-509590-23-00

Locations: 🇧🇬
Specialized Hospital For Active Treatment Of Hematological Diseases EAD, Sofiya, Bulgaria
🇵🇱
Instytut Hematologii I Transfuzjologii, Warsaw, Poland

Long-term Follow-up Study of Male Adults With Hemophilia B Previously Treated With Etranacogene Dezaparvovec (CSL222)

Conditions: Hemophilia B

Interventions: Genetic: AAV5-hFIXco-Padua

First Posted Date: 2023-07-27

Last Posted Date: 2025-06-13

Lead Sponsor: CSL Behring

Target Recruit Count: 56

Registration Number: NCT05962398

Locations: 🇺🇸
10-15 Phoenix Childrens Hospital, Phoenix, Arizona, United States
🇺🇸
10-14 Arkansas Children's Hospital - Pharmacology, Little Rock, Arkansas, United States
🇺🇸
10-22 Orthopaedic Institute for Children, Los Angeles, California, United States

and more 25 locations

First-In-Human Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Escalating Single And Multiple Doses Of CSL040 In Healthy Subjects

Phase 1

Recruiting

Conditions: Disease Driven by Complement Activation

Interventions: Drug: CSL040
Drug: Placebo

First Posted Date: 2023-07-10

Last Posted Date: 2025-04-02

Lead Sponsor: CSL Behring

Target Recruit Count: 60

Registration Number: NCT05937581

Locations: 🇦🇺
Nucleus Network Pty Ltd, Herston, Queensland, Australia

CSL312_3003 Safety and Pharmacokinetic Study in Subjects 2 to 11 Years of Age With Hereditary Angioedema

Phase 3

Active, not recruiting

Conditions: Hereditary Angioedema (HAE)

Interventions: Biological: CSL312

First Posted Date: 2023-04-19

Last Posted Date: 2025-06-02

Lead Sponsor: CSL Behring

Target Recruit Count: 20

Registration Number: NCT05819775

Locations: 🇺🇸
Research Solutions of Arizona, Litchfield Park, Arizona, United States
🇺🇸
Medical Research of Arizona, Scottsdale, Arizona, United States
🇺🇸
Donald S. Levy M.D., Orange, California, United States

and more 10 locations

Effects of CSL324 in the Lung After Segmental Challenge

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: CSL324
Drug: Placebo

First Posted Date: 2022-12-16

Last Posted Date: 2023-11-29

Lead Sponsor: CSL Behring

Target Recruit Count: 40

Registration Number: NCT05653713

Locations: 🇩🇪
Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( TAP Study )

Phase 3

Terminated

Conditions: Traumatic Injury

Interventions: Drug: BE1116
Drug: Placebo

First Posted Date: 2022-10-06

Last Posted Date: 2024-11-01

Lead Sponsor: CSL Behring

Target Recruit Count: 1370

Registration Number: NCT05568888

Locations: 🇺🇸
UAB Hospital, Birmingham, Alabama, United States
🇺🇸
University of South Alabama, Mobile, Alabama, United States
🇺🇸
Chandler Regional Medical Center, Chandler, Arizona, United States

and more 108 locations

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis

Phase 2

Recruiting

Conditions: Atherosclerotic Cardiovascular Disease
End Stage Kidney Disease
Atherosclerotic Cardiovascular Disease in Patients With ESKD

Interventions: Drug: Placebo
Drug: CSL300

First Posted Date: 2022-08-03

Last Posted Date: 2025-06-19

Lead Sponsor: CSL Behring

Target Recruit Count: 2310

Registration Number: NCT05485961

Locations: 🇺🇸
84000149 - Nephrology Consultants, LLC, Huntsville, Alabama, United States
🇺🇸
84000340 - DaVita Clinical Research Montgomery, Montgomery, Alabama, United States
🇺🇸
84000552 - AKDHC Medical, Glendale, Arizona, United States

and more 295 locations

Assess Burden of Disease Among Kidney Transplant Recipients With Chronic Active Antibody Mediated Rejection

Completed

Conditions: Antibody-mediated Rejection in Kidney Transplant

Interventions: Other: Non-Chronic active AMR group
Other: Chronic active AMR group

First Posted Date: 2022-07-11

Last Posted Date: 2023-04-13

Lead Sponsor: CSL Behring

Target Recruit Count: 52

Registration Number: NCT05452317

Locations: 🇺🇸
Keck Medical Center of USC, Los Angeles, California, United States
🇺🇸
University of Maryland School of Medicine, Div. of Nephrology, Baltimore, Maryland, United States
🇺🇸
The Washington University, Saint Louis, Missouri, United States

Study of AAV5-hFIX in Severe or Moderately Severe Haemophilia B

Active, not recruiting

Conditions: Hemophilia B

Interventions: Genetic: AAV5-hFIX

First Posted Date: 2022-05-04

Last Posted Date: 2025-06-19

Lead Sponsor: CSL Behring

Target Recruit Count: 9

Registration Number: NCT05360706

Locations: 🇩🇪
Vivantes Klinikum im Friedrichshain, Berlin, Germany
🇩🇪
Universitaetsklinikum Frankfurt - Klinikum der Johann Wolfgang Goethe Universitaet, Frankfurt, Germany
🇳🇱
Amsterdam UMC - Locatie AMC, Amsterdam, Netherlands

and more 3 locations

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