Merus NV
- Country
- 🇳🇱Netherlands
- Ownership
- Public
- Established
- 2003-01-01
- Employees
- 229
- Market Cap
- $3.6B
- Website
- http://www.merus.nl
Clinical Trials
38
Trial Phases
3 Phases
Drug Approvals
0
Drug Approvals
No drug approvals found
This company may not have drug approvals in our database
Clinical Trials
Distribution across different clinical trial phases (30 trials with phase data)• Click on a phase to view related trials
A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)
- Conditions
- Head and Neck Squamous Cell Carcinoma
- Interventions
- First Posted Date
- 2024-07-29
- Last Posted Date
- 2025-11-03
- Lead Sponsor
- Merus N.V.
- Target Recruit Count
- 500
- Registration Number
- NCT06525220
- Locations
- 🇺🇸
Site 164, Mobile, Alabama, United States
🇺🇸Site 162, Baton Rouge, Louisiana, United States
🇲🇾Site 163, Johor Bahru, Malaysia
A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients
- Conditions
- Head and Neck Squamous Cell Carcinoma
- Interventions
- Drug: Investigator's Choice
- First Posted Date
- 2024-07-11
- Last Posted Date
- 2025-11-04
- Lead Sponsor
- Merus N.V.
- Target Recruit Count
- 500
- Registration Number
- NCT06496178
- Locations
- 🇨🇦
Site 172, Montreal, Canada
🇬🇧Site 171, Glasgow, United Kingdom
🇺🇸Site 160, Mobile, Alabama, United States
Study Evaluating Zenocutuzumab in Patients With or Without Molecularly Defined Cancers
- Conditions
- NSCLC Harboring NRG1 FusionMetastatic Castration-resistant Prostate Cancer
- Interventions
- First Posted Date
- 2022-10-20
- Last Posted Date
- 2025-09-18
- Lead Sponsor
- Merus N.V.
- Target Recruit Count
- 13
- Registration Number
- NCT05588609
- Locations
- 🇺🇸
The Oncology Institute of Hope & Innovation, Whittier, California, United States
🇺🇸Florida Cancer Specialists, Lake Mary, Florida, United States
🇺🇸The Center for Cancer and Blood Disorders, Bethesda, Maryland, United States
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
- Conditions
- Non-Small Cell Lung Cancer MetastaticColorectal CancerEsophageal Squamous Cell CarcinomaHead and Neck Squamous Cell CarcinomaGastric Cancer
- Interventions
- First Posted Date
- 2021-05-03
- Last Posted Date
- 2025-06-26
- Lead Sponsor
- Merus N.V.
- Target Recruit Count
- 576
- Registration Number
- NCT04868877
- Locations
- 🇺🇸
University of California, Irvine, Orange, California, United States
🇺🇸Sarah Cannon Research Institute, Nashville, Tennessee, United States
🇺🇸START Mountain Region, West Valley City, Utah, United States
Early Access Program Providing HER2/HER3 Bispecific Antibody, MCLA-128, for a Patient With Advanced NRG1-Fusion Positive Solid Tumor
- Conditions
- NRG1 FusionPancreatic CancerNon Small Cell Lung CancerSolid Tumor, Unspecified, AdultProstate CancerHead and Neck CancerColorectal CancerBreast CancerCholangiocarcinomaRenal Cell Carcinoma
- First Posted Date
- 2019-09-24
- Last Posted Date
- 2025-05-20
- Lead Sponsor
- Merus N.V.
- Registration Number
- NCT04100694
- Prev
- 1
- 2
- Next
News
Genmab Reports Strong Q3 2025 Results with Key Pipeline Advances and $8 Billion Merus Acquisition
Genmab achieved 21% revenue growth to $2.66 billion in the first nine months of 2025, driven primarily by increased DARZALEX and Kesimpta royalties.
Abivax Phase III Success Triggers 850% Stock Surge, Reignites European Biotech Rally
Abivax shares soared over 850% following positive Phase III data in ulcerative colitis, creating an "Abivax effect" that has reshaped market dynamics and reignited investor confidence in European biotech.
Zenocutuzumab Shows 37% Response Rate in Rare NRG1-Positive Cholangiocarcinoma
Zenocutuzumab demonstrated a 37% objective response rate in 19 patients with NRG1-positive cholangiocarcinoma in the phase II eNRGy trial, with a median duration of response of 7.4 months.
Merus' Petosemtamab Phase 2 Data Selected for Plenary Presentation at AACR-NCI-EORTC Conference
Merus announced that interim data from its phase 2 trial of petosemtamab in metastatic colorectal cancer has been selected for a prestigious plenary session oral presentation at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.
Biopharma M&A Activity Surges in Q3 2025 with $55.7 Billion in Acquisitions
The biopharmaceutical sector experienced a significant surge in high-value acquisitions during Q3 2025, with four of the year's five largest deals occurring in the past four months.
Genmab Announces $5.2 Billion Acquisition of Merus to Expand Late-Stage Oncology Pipeline
Genmab will acquire Merus for $97.00 per share, representing a 41% premium and totaling approximately $5.2 billion in the largest deal in Genmab's history.
Biohaven's Novel ADCs Show Promising Early Clinical Results with TopoIx Payload Technology
Biohaven's Trop2-directed ADC BHV-1510 demonstrated tumor reduction in all six patients when combined with cemiplimab, including confirmed partial responses and activity in brain metastases.
Merus Reports Promising Survival Data for Petosemtamab-Keytruda Combination in Metastatic Head and Neck Cancer
Merus announced that 79% of patients with newly diagnosed metastatic head and neck cancer survived at least one year when treated with petosemtamab in combination with Keytruda.
Merus to Present Petosemtamab Combination Therapy Data for Head and Neck Cancer at 2025 ASCO Meeting
Merus will present updated interim Phase 2 data on petosemtamab combined with pembrolizumab for first-line treatment of PD-L1+ recurrent/metastatic head and neck squamous cell carcinoma at the 2025 ASCO Annual Meeting.
FDA Grants Second Breakthrough Therapy Designation for Petosemtamab in Head and Neck Cancer
Merus N.V.'s petosemtamab receives FDA Breakthrough Therapy designation for first-line treatment of PD-L1 positive head and neck cancer when combined with pembrolizumab.
