THE SCRIPPS RESEARCH INSTITUTE

Researchers discovered human antibodies targeting PfEMP1 proteins in severe malaria, potentially leading to vaccines or treatments. These antibodies, found effective against various PfEMP1 types, prevent parasite binding by recognizing conserved amino acids on CIDRα1, offering insights for PfEMP1-based interventions.

The article introduces Daniel Beck and Karson Putt as authors, detailing their extensive backgrounds in medicinal chemistry and drug discovery, respectively. It also mentions reviewers Pablo Martín-Gago and Ravi Kurumbail, highlighting their significant contributions to the field, particularly in hit discovery and structural biology.