MAYO CLINIC

A2 Bio presented updates on Tmod™ CAR T-cell clinical programs at SITC 2024, including BASECAMP-1's enhancements for participant diversity and EVEREST-1/2 enrollment progress, highlighting early safety and biomarker data.

First larynx transplant at Mayo Clinic, involving 6 surgeons and 20 staff, marks a medical milestone as the first total larynx transplant in a U.S. clinical trial for a patient with active cancer. The 21-hour procedure included eight types of tissue and aims to improve the patient's ability to talk, swallow, and breathe. Led by Dr. David G. Lott and Dr. Girish K. Mour, the surgery is part of a clinical trial researching the safety and efficacy of larynx transplants, with the patient showing significant progress four months post-surgery.

John Sims presented at CTAD that starting donanemab at low doses and titrating up reduced ARIA-E by 40%, especially for APOE homozygotes. Gil Rabinovici's new donanemab AUR emphasize stricter MRI criteria for safety. Lilly plans to submit data to update the label.

Medical advancements like tooth regrowth, cancer vaccines, CRISPR gene editing, lab-grown organs, artificial blood, bionic eyes, Alzheimer’s treatments, targeted drug delivery for childhood brain tumors, stem cell therapy for spinal cord injuries, and personalized medicine are transforming healthcare, offering new possibilities for improved health and longevity.

Oliver Sartor and Louise Emmett discuss combination therapy approaches with lutetium-PSMA in prostate cancer, focusing on strategies like hormonal therapies, taxanes, DNA repair inhibitors, immunotherapy, and dual isotope treatments. They highlight the ENZA-p trial's promising results, emphasizing the need for rational, well-tolerated combinations tailored to disease stage and patient needs, while managing toxicity profiles.

Becker's 2024 list highlights hospitals & health systems excelling in oncology, recognized for advanced clinical trials & research. Notable institutions include AdventHealth, Allina Health, Arkansas Children's, Atlantic Health System, Banner MD Anderson Cancer Center, Baylor Scott & White Health, Boston Medical Center, Brown University Health, Children's Health, Children's Hospital Colorado, Children’s Hospital Los Angeles, Children’s Hospital of Orange County, Children's Hospital of Philadelphia, Children's Nebraska, ChristianaCare, City of Hope Comprehensive Cancer Center, Cleveland Clinic, Connecticut Children’s, Covenant Health, Dana-Farber Cancer Institute, Dartmouth Health, DeTar Hospital Cancer Center, Duke Health, El Paso Children's Hospital, Emory Healthcare, Endeavor Health, Fred Hutchinson Cancer Center/UW Medicine, Geisinger, Hackensack Meridian Health, Huntsman Cancer Institute at the University of Utah, Inova, Jefferson Health, Johns Hopkins, Jupiter Medical Center, Keck Medicine of USC, Laredo Medical Center, Lehigh Valley Health Network, MUSC Health, MaineHealth, Massachusetts General Hospital, Mayo Clinic, MedStar, MemorialCare, Memorial Sloan Kettering Cancer Center, Michigan Medicine, Mount Sinai Health System, Nebraska Medicine, New York-Presbyterian Hospital-Columbia and Cornell, Northwestern Medicine, Novant Health, OSF HealthCare, OU Health, Ochsner Health, Ohio State University Comprehensive Cancer Center, Oregon Health & Science University Hospital, Orlando Health, Penn Medicine, Providence Alaska Medical Center, Providence Cancer Institute of Oregon, Providence South Division Cancer Institute, Queen's Health System, RWJBarnabas Health and Rutgers Cancer Institute, Renown Health, Rochester Regional Health, Roper St. Francis Healthcare, Roswell Park Comprehensive Cancer Center, Sanford Health, Sarasota Memorial Health Care System, Scripps Health, St. Jude Children's Research Hospital, Stanford Medicine, Stanford Medicine Children's Health, Sutter Health, Swedish Cancer Institute, Sylvester Comprehensive Cancer Center at University of Miami, Tampa General Hospital, Texas Children's Hospital, UC Davis Health, UCLA Health, UCSF Health, UK HealthCare, UNM Health System, UVA Health, UW Health, UMass Memorial Health, University of Alabama Birmingham Hospital, University of Chicago Medical Center, University of Colorado Cancer Center-UCHealth University of Colorado Hospital, University Hospitals, University of Iowa Health Care, University of Kansas Health System, University of Texas MD Anderson Cancer Center, University of Vermont Health Network, Vanderbilt University Medical Center, Virtua Health, WVU Cancer Institute, WellSpan Health, Yale New Haven Health.

Researchers debate replacing cognitive tests with blood tests and brain scans for early Alzheimer’s diagnosis, with proponents arguing biomarkers detect the disease at its earliest, treatable stage, while critics warn of potential distress and misdiagnosis for asymptomatic individuals.

Mayo Clinic researchers developed GMWI2, an AI tool analyzing gut microbiome to predict health trends, achieving 80% accuracy in distinguishing healthy from diseased individuals. The tool aims to inform proactive health measures and may lead to new biomarkers for predictive healthcare.

PDS Biotech is preparing a Phase 3 trial for Versamune HPV + pembrolizumab as a first-line treatment for recurrent or metastatic HPV16-positive HNSCC. CEO Frank Bedu-Addo discusses the company's history, technology, and clinical successes, including Versamune HPV's potential in HPV-positive cancers with a TAM exceeding $6B in the U.S.