Dr. Nir Barzilai predicts impactful gerotherapeutics will take decades to reach the average person. Successful gerotherapy must target aging hallmarks, extend health span, undergo extensive clinical trials, and influence all-cause mortality. Four FDA-approved drugs show promise: GLP-1s, SGLT2 inhibitors, bisphosphonates, and metformin. Despite their potential, these drugs are not approved for anti-aging alone and are intended for those with pre-existing conditions. Lifestyle changes remain crucial for healthy aging.