The TOPSPIN study, conducted by the Centre for Chronic Disease Control in collaboration with AIIMS and Imperial College London, has demonstrated the effectiveness of three double anti-hypertensive pill combinations in South Asian populations with uncontrolled hypertension. The study found that all three combinations were equally effective and safe, achieving blood pressure control in approximately 70% of participants. This research provides a significant advancement in hypertension management for South Asians, offering clinicians a roadmap for treatment.