JOHN HOPE FRANKLIN CENTER

Lexeo Therapeutics' LX1001, an AAV vector-based gene therapy, demonstrated dose- and time-dependent APOE2 expression in APOE4 homozygote Alzheimer disease patients, with decreases in CSF AD tau biomarkers and tau PET changes. The therapy was safe and well-tolerated, with no ARIA cases reported, and offers potential to slow AD progression by converting APOE4 homozygosity to APOE2/E4 heterozygosity.

A digital intervention combining text messages and a web-based dashboard, added to health behavior counseling, improved weight-for-length trajectories and reduced obesity incidence at 24 months in a diverse population, compared to counseling alone.

Sermonix Pharmaceuticals and Quantum Leap Healthcare Collaborative report lasofoxifene, an investigational drug, showed promising early activity in suppressing Ki67 protein in a Phase 2 clinical trial for HR+/HER2-, locally advanced breast cancer, with good tolerability in both premenopausal and postmenopausal patients.

Sermonix Pharmaceuticals and Quantum Leap Healthcare Collaborative announce lasofoxifene's promising early activity in suppressing Ki67 in HR+/HER2-, locally advanced breast cancer patients, with well-tolerated side effects in a Phase 2 clinical trial.

Geneial, in collaboration with RENCI, NHLBI BioData Catalyst, and ARPA-H, develops AI tools to streamline biomedical data transformation, reducing costs and enhancing access in precision medicine.

Geneial awarded pilot project by NHLBI BioData Catalyst® and RENCI to advance AI tools for biomedical data standardization, collaborating with ARPA-H BDF Toolbox program to enhance precision medicine research. Geneial's AI tools automate data conversion to GA4GH Phenopackets format, reducing costs and improving data utility, aligning with a vision of global, privacy-preserving data exchange.

Deep learning is crucial for light field microscopy image reconstruction. This review explores recent advancements, categorizing deep learning-based methods into fully deep learning, deep learning enhanced raw light field image with numerical inversion volumetric reconstruction, and numerical inversion volumetric reconstruction with deep learning enhanced resolution. Challenges include improving accuracy, obtaining training data, data enhancement, and interpretability of deep neural networks.

Duke University’s Margolis Institute of Health Policy paper on AI governance in healthcare outlines key components and suggests ways to set up governance systems. It describes five variations: decision-making authority, governance committee composition, role of the patient voice, governance scope, and tool identification. The paper emphasizes aligning innovation, accountability, and trust.

At the STRIPE Annual Meeting & Consensus Workshop, ASP announced the inaugural STRIPE Double Helix Awards, recognizing excellence in pharmacogenomics through collaboration and outstanding achievement. Recipients include Kristine Ashcraft, Cynthia Bens, Burns C. Blaxall, Philip Empey, Jose Estabil, Bernard Esquivel, Christine Formea, Blaine Groat, Daniel Hertz, Carrie Hoefer, Geoff Hollett, J. Shawn Jones, Raymond Lorenz, Ryan Nelson, Micheal Pacanowski, Jai N. Patel, Victoria Pratt, Bronwyn Ramey, Sharmeen Roy, Robert Schuck, April Schultz, Jeffrey A. Shaman, Sharon Shriver, Patrick Silva, D. Max Smith, Annette Taylor, Wrenda Teeple, McKenna Tennant, Kelly E. Caudle, Emily Cicali, Andrea Gaedigk, Houda Houchad, Pamala Jacobson, Teri E. Klein, Akinyemi Oni-Orisan, Natasha Petry, Bani Tamraz, Kristin Wiisanen, and Michelle Whirl-Carrillo. Organizations honored include the Golden Helix Foundation, Department of Veteran Affairs - National Pharmacogenomics Program, and Advocates for Universal DPD/DPYD Testing.