JOHN HOPE FRANKLIN CENTER

Patient-centric clinical trials, involving patients early and often, lead to better outcomes, faster completion, and cost efficiency. Key strategies include engaging patient advocacy groups, decentralizing trials, and reducing patient burden, enhancing recruitment, retention, and trial relevance.

GUARD-AF trial at ESC Congress 2024 showed Zio XT patch-based LTCM increased AF diagnosis (5.0% vs 3.3%) but no stroke reduction due to low event rates and truncated enrollment.