相关临床试验
186
17 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1900
进行中（未招募）
10
5.4%
已完成
112
60.2%
Enrolling By Invitation
3
1.6%
尚未招募
4
2.1%
招募中
28
15.1%
暂停
1
0.5%
终止
12
6.5%
Unknown
6
3.2%
撤回
10
5.4%
暂无批准数据
- Researchers developed predictive models that accurately distinguish mild, moderate, and severe community-acquired pneumonia in children aged 3 months to 14 years with a c-statistic of 0.82. - The multinational study analyzed 2,222 children across 73 emergency departments in 14 countries, finding that 5.4% developed severe pneumonia requiring intensive interventions. - Key risk factors for severe disease include hypoxemia, chest retractions, elevated vital signs, and abdominal pain, while congestion or rhinorrhea were protective against severe outcomes. - The models demonstrate superior performance compared to clinician judgment alone and could help reduce unnecessary hospitalizations while ensuring early identification of high-risk patients.
- Recent CDC data reveals a significant increase in anxiety rates among U.S. adults, rising from 15.6% in 2019 to 18.2% in 2022, with young adults aged 18-29 experiencing the highest prevalence at 26.6%. - Depression rates have similarly climbed from 18.5% to 21.4% during the same period, disproportionately affecting younger Americans, with nearly 27% of young adults reporting depressive symptoms. - The mental health crisis extends to children and adolescents, with anxiety increasing from 7.1% in 2016 to 10.6% in 2022, and depression rising from 3.2% to 4.6%, highlighting an urgent need for targeted interventions.
- A decade-long study of 260 adolescents who underwent weight-loss surgery revealed sustained 20% BMI reduction and significant improvements in obesity-related health conditions. - The research published in NEJM found that 55% of teens with type 2 diabetes remained in remission after 10 years, substantially higher than the 12-18% remission rates observed in adults. - Despite nearly 5 million teenagers being eligible for bariatric procedures, only 1 in 2,500 adolescents with severe obesity currently receive this potentially life-changing intervention.
- A comprehensive analysis of 4,527 clinical trials from 2015-2020 reveals that less than half of trials, whether NIH or industry-funded, focus on the top 20 childhood disease categories. - NIH funding proves crucial for pediatric research areas overlooked by industry, particularly in cancer and other critical childhood diseases, highlighting its vital role in advancing children's healthcare. - Key pediatric conditions including neonatal disorders, congenital birth defects, and asthma remain significantly underfunded relative to their disease burden, calling for increased research prioritization.
