University of Bergen

Mitochondrial NAD+ Reservoir Vital for Cellular Health and Aging, Study Finds

5 months ago

• Researchers have discovered that mitochondria act as a crucial reservoir for NAD+, a molecule essential for cellular energy and function, maintaining cellular health. • The study reveals that mitochondrial dysfunction and depletion of NAD+ are linked to aging and age-related disorders like neurodegenerative diseases. • Supplementation strategies to increase NAD+ levels have shown promising results in initial clinical trials, suggesting a potential therapeutic avenue for aging-related conditions. • Using advanced techniques, the study elucidated the molecular mechanisms by which mitochondria counteract cellular NAD+ decline, highlighting the importance of basic research in identifying targets for aging and disease.