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Third Harmonic Bio

Third Harmonic Bio logo
🇺🇸United States
Ownership
Public
Established
2019-01-01
Employees
30
Market Cap
$507.5M
Website
http://thirdharmonicbio.com
Introduction

Third Harmonic Bio, Inc. develops pharmaceutical products for the treatment of allergic and immune diseases and disorders. It focuses on the development of the next wave of medicine for the treatment of allergic and inflammatory diseases. The company was founded on April 25, 2019 and is headquartered in San Francisco, CA.

Clinical Trials

8

Active:0
Completed:5

Trial Phases

1 Phases

Phase 1:2

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (2 trials with phase data)• Click on a phase to view related trials

Phase 1
2 (100.0%)

A First in Human Trial Evaluating THB335 in Healthy Participants

Phase 1
Recruiting
Conditions
Healthy
Interventions
Drug: THB335 single dose
Drug: THB335 fasted/fed
Drug: THB335 multiple dose
Drug: Single dose placebo
Drug: Placebo fasted/fed
Drug: Multiple dose placebo
First Posted Date
2024-05-22
Last Posted Date
2024-05-22
Lead Sponsor
Third Harmonic Bio, Inc.
Target Recruit Count
56
Registration Number
NCT06425861
Locations
🇺🇸

QPS Miami, Miami, Florida, United States

A Study to Evaluate THB001 in Adult Patients With Chronic Cold Urticaria

Phase 1
Terminated
Conditions
Chronic Cold Urticaria
Interventions
First Posted Date
2022-08-22
Last Posted Date
2023-10-10
Lead Sponsor
Third Harmonic Bio, Inc.
Target Recruit Count
5
Registration Number
NCT05510843
Locations
🇩🇪

Charité - Universitätsmedizin Berlin Institute of Allergology, Berlin, Germany

🇳🇱

Centre for Human Drug Research, Leiden, Netherlands

News

Tang Capital's Concentra Biosciences Acquires Elevation Oncology for $0.36 Per Share in Latest Biotech Liquidation

Elevation Oncology has agreed to be acquired by Concentra Biosciences, controlled by hedge fund Tang Capital Partners, for $0.36 per share in cash with additional contingent value rights.

Biotech Funding Plummets 57% to $2.7 Billion as Trump Administration Policies Shake Investor Confidence

Biotech funding dropped 57% to $2.7 billion in May 2025, marking one of the worst funding periods in three years according to Jefferies investment bank analysis.

Third Harmonic Bio Stockholders Approve Liquidation Plan as THB335 Shows 85% Tryptase Reduction in Phase 1 Trial

Third Harmonic Bio stockholders overwhelmingly approved a liquidation and dissolution plan with 99.9% of voting shares supporting the proposal at the June 5, 2025 annual meeting.

Third Harmonic Bio's THB335 Shows Promising Phase 1 Results for Chronic Urticaria Treatment

Third Harmonic Bio's Phase 1 trial of THB335, a selective KIT inhibitor, demonstrated favorable safety profile and pharmacokinetics supporting once-daily dosing in healthy volunteers.

Blueprint Medicines' BLU-808 Shows Superior Profile Over Third Harmonic's THB001 in KIT Inhibitor Race

Blueprint Medicines reports promising Phase 1 data for BLU-808, demonstrating favorable pharmacokinetics supporting once-daily dosing in healthy volunteers.

Third Harmonic Bio Appoints Geoff McDonough to Board of Directors, Advancing THB335 for Chronic Spontaneous Urticaria

Third Harmonic Bio appointed Geoff McDonough, M.D., to its Board of Directors, enhancing its leadership with extensive clinical and commercial experience.

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