• OrthoTrophix has initiated a Phase 2b clinical trial of TPX-100, a potential disease-modifying osteoarthritis drug (DMOAD) for patients with mild to severe knee osteoarthritis in the United States.
• Previous Phase 2a results showed TPX-100 significantly improved knee function and reduced structural deterioration in subchondral bone compared to placebo, addressing a key predictor of disease progression.
• The 53-week study aims to confirm both symptomatic improvements and structural effects, potentially representing a breakthrough in knee OA treatment beyond symptom management.