Korea University Guro Hospital

The SPROUT-4 trial is a multicenter, randomized controlled study in South Korea, focusing on individualized vs. conventional blood pressure management in high-risk patients undergoing major noncardiac surgery. It aims to reduce postoperative complications, with outcomes assessed within 7 days post-surgery.

Researchers developed a technique using neo-mannosyl human serum albumin-indocyanine green (MSA-ICG) and laparoscopic fluorescence imaging to detect and remove metastatic lymph nodes in endometrial cancer surgery, reducing complications and improving survival rates.

A multicenter, randomized, double-blind study evaluated the antihypertensive efficacy and safety of AML plus CC versus AML monotherapy in Korean patients with uncontrolled essential hypertension. Patients underwent a 4-week AML monotherapy run-in period, followed by randomization to combination therapy or AML monotherapy for 8 weeks. The primary outcome was DBP change at week 8, with additional assessments at weeks 4, 12, and 16. Safety was monitored through adverse events. The study aimed for KMFDS approval for the AML/CC fixed-dose combination.