GlaxoSmithKline

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GSK discontinues phase III HSV vaccine development after phase II trial failure. No safety concerns noted. GSK remains committed to innovative genital herpes treatments.

BioVersys secures $6m investment from GIBF2 for BV100 development in China, targeting CRAB infections. Phase 1 study to start in 1H 2025, leading to global Phase 3 trial.

Depemokimab, an ultra-long-acting biologic targeting IL-5, showed significant reduction in asthma exacerbations in 2 phase 3 trials (SWIFT-1 and SWIFT-2) for severe asthma with type 2 inflammation. The therapy met primary and key secondary endpoints, including reducing hospitalizations and emergency visits, though quality-of-life improvements were not statistically significant. Depemokimab, with 6-month dosing intervals, could be the first of its kind approved, offering potential benefits for severe asthma management.

GSK's Phase III trials of depemokimab in severe asthma showed a 54% reduction in exacerbations and a 72% reduction in hospitalisations. Safety profile was similar to placebo, with no related deaths or serious AEs.

GSK’s depemokimab, an ultra-long-acting biologic, significantly reduced severe asthma exacerbations by 54% over one year in phase 3 trials, with a 72% reduction in hospitalisations or emergency visits. Despite non-significant improvements in quality of life, the data supports global regulatory filings.

GSK's Phase III trials of depemokimab in severe asthma patients with elevated blood eosinophil counts showed a 54% reduction in exacerbations and a 72% reduction in hospitalisations or emergency visits. The treatment's safety profile was comparable to placebo.