Great Ormond Street Hospital for Children NHS Foundation Trust
๐ฌ๐งUnited Kingdom
Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases
Not Applicable
Completed
- Conditions
- Esophageal Atresia With Tracheo-esophageal FistulaCongenital Diaphragmatic Hernia
- Interventions
- Procedure: Hypercapnia during thoracoscopyProcedure: Open surgery
- First Posted Date
- 2011-11-08
- Last Posted Date
- 2022-03-02
- Target Recruit Count
- 20
- Registration Number
- NCT01467245
- Locations
- ๐ฌ๐ง
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
NEMO1:NEonatal Seizure Using Medication Off-patent
- First Posted Date
- 2011-09-14
- Last Posted Date
- 2015-09-14
- Target Recruit Count
- 14
- Registration Number
- NCT01434225
- Locations
- ๐ฎ๐ช
Cork University Maternity Hospital, Cork, Ireland
๐ณ๐ฑErasmus Universitair Medisch Centrum Rotterdam, Rotterdam, Netherlands
๐ณ๐ฑUniversity Medical Centre Utrecht, Utrecht, Netherlands
Lentiviral Gene Therapy for X-Linked Chronic Granulomatous Disease (X-CGD)
Phase 1
Withdrawn
- Conditions
- Granulomatous Disease, Chronic, X-linked, Variant
- Interventions
- Genetic: pCCLchimGp91s lentiviral vector transduced CD34+ cells infusion
- Locations
- ๐ฌ๐ง
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency
Phase 1
Completed
- Conditions
- Adenosine Deaminase DeficiencySevere Combined Immunodeficiencies (SCID)
- Interventions
- Other: Haematopoietic Stem Cell Transplantation (HSCT)Genetic: Infusion of autologous EFS-ADA LV CD34+ cellsDrug: BusulfanDrug: Peg-Ada
- First Posted Date
- 2011-06-27
- Last Posted Date
- 2021-09-16
- Target Recruit Count
- 36
- Registration Number
- NCT01380990
- Locations
- ๐ฌ๐ง
Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
Therapeutic Controlled Hypothermia in the Treatment of Neonates With Severe Necrotizing Enterocolitis
Not Applicable
Terminated
- Conditions
- Necrotizing Enterocolitis
- Interventions
- Procedure: cooling blanket/mattressProcedure: Standard treatment of care at normothermia
- First Posted Date
- 2011-04-07
- Last Posted Date
- 2022-02-03
- Target Recruit Count
- 13
- Registration Number
- NCT01330576
- Locations
- ๐ฌ๐ง
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Gene Therapy ADA Deficiency
Phase 1
Completed
- Conditions
- Adenosine Deaminase Deficiency
- Interventions
- Biological: Intravenous infusion of transduced cells
- First Posted Date
- 2011-01-19
- Last Posted Date
- 2015-09-14
- Target Recruit Count
- 8
- Registration Number
- NCT01279720
- Locations
- ๐ฌ๐ง
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Suicide Gene Therapy Trial
Phase 1
Terminated
- Conditions
- Haploidentical Stem Cell Transplantation
- Interventions
- Biological: HSVTK retrovirally-transduced donor T lymphocytes
- First Posted Date
- 2010-09-17
- Last Posted Date
- 2013-09-18
- Target Recruit Count
- 2
- Registration Number
- NCT01204502
- Locations
- ๐ฌ๐ง
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Gene Therapy for X-linked Severe Combined Immunodeficiency (SCID-X1)
Not Applicable
- Conditions
- X-linked Severe Combined Immunodeficiency
- Interventions
- Genetic: Single infusion of autologous CD34+ cells transduced with the self-inactivating (SIN) gammaretroviral vector pSRS11.EFS.IL2RG.pre
- First Posted Date
- 2010-08-04
- Last Posted Date
- 2017-08-01
- Target Recruit Count
- 1
- Registration Number
- NCT01175239
- Locations
- ๐ฌ๐ง
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
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