University of California, Los Angeles

University of Arizona's research activity exceeded $1 billion in FY24, focusing on global challenges like energy, health, and national security. The university ranks among top research institutions and maintains its No. 1 ranking in astronomy and astrophysics. Research advances human knowledge, prepares students, and strengthens communities.

Jeremie Calais, MD, PhD, discusses the 'Standardized template for clinical reporting of PSMA PET/CT scans,' detailing a table integrating miTNM, PROMISE, PRIMARY, RECIP, PSMA-RADS, and E-PSMA criteria. It includes patient history, scan indications, staging, PSMA expression, technical details, and lesion assessments.

Juan J. Andino, MD, MBA, discusses workforce shortages in urology and oncology, emphasizing the importance of telehealth in addressing access to care. He highlights ongoing public policy work and the potential expiration of telehealth flexibilities, which could revert access to pre-pandemic levels, impacting care negatively.

C22.1: KS1 iPSCs showed lower functional KMT2D expression, H3K4me1/2 levels, and differential gene expression related to KS1 phenotypes. C22.2: Single-cell genomics identified cell-type variation in expression and chromatin, regulatory elements, and eQTLs, facilitating precision medicine for neuropsychiatric disorders. C22.3: XDP-TE in TAF1 gene linked to XDP; ZNF91 establishes H3K9me3 and DNA methylation, crucial for TAF1 regulation. C22.4: MORC2 mutations cause diverse neurological disorders; multi-omics analysis revealed DNA methylation and transcriptome signatures, linking epigenetic silencing to phenotypic manifestation. C22.5: SIRT6 knockdown in Drosophila neurons reduced movement; in neuroblasts, it was lethal, highlighting its role in neurodevelopment. C22.6: Long-read genome sequencing improved diagnostic sensitivity, identified ZFHX3 GGC-repeat expansion as SCA4 cause, and demonstrated abnormal autophagy in affected cells.

UCLA researchers developed a nanosystem to deliver glucagon precisely when needed, preventing hypoglycemia in mice by releasing glucagon in response to falling glucose levels, offering a potential preventive therapy for diabetes.

Temporary scalp tattoos effectively track brainwaves, outperforming conventional electrodes in ease of application and duration, according to a study in 'Cell Biomaterials'. The e-tattoos, made with conductive polymers, maintain stable connectivity for 24 hours and could revolutionize noninvasive brain-computer interfaces.

Nervonik, a medical device startup, completed its first-in-human clinical study for peripheral nerve stimulation (PNS) to treat chronic pain. The study, conducted in Panama City, involved surgically implanted leads connected to miniaturized implantable pulse generators, customized via a dedicated app. The results are expected to be presented in early 2025.

GCAR and AstraZeneca will evaluate AZD1390 in GBM AGILE trial for newly diagnosed glioblastoma, with recruitment starting Q2 2025. GBM AGILE, the first global adaptive platform trial for glioblastoma, aims to identify effective therapies through adaptive randomization. AZD1390, an ATM kinase inhibitor, showed preliminary efficacy and manageable safety profile in Phase I data.

Integrating exclusive liquid meal replacement with Soylent in head and neck cancer patients undergoing chemoradiation resulted in high adherence and a 5% gastrostomy tube placement rate. Quality of life measures showed initial decline but rebounded by 6 months post-CRT.