The McLean Hospital Corporation

High-dose prescription amphetamine users face over five-fold increased risk of psychosis or mania, with 30 mg+ dextroamphetamine (40 mg Adderall) posing the highest risk, according to McLean Hospital research. The study, published in the American Journal of Psychiatry, highlights the need for dose consideration in prescribing stimulants, with 81% of psychosis or mania cases in high-dose users potentially preventable. No significant risk increase was observed with methylphenidate (Ritalin) use.

High Adderall doses linked to fivefold increased risk of first-time psychosis or mania, especially above 40 mg.

High doses of ADHD meds like Adderall can increase psychosis risk by over fivefold, with 30mg+ dextroamphetamine (40mg Adderall) posing the highest risk, according to a study in the American Journal of Psychiatry. Dr. Lauren Moran emphasizes dose as a critical factor in psychosis risk and suggests considering alternative ADHD treatments like methylphenidate (Ritalin), which showed no increased risk.