相关临床试验
20
2 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1969
进行中（未招募）
1
5.0%
已完成
10
50.0%
尚未招募
1
5.0%
招募中
4
20.0%
终止
1
5.0%
Unknown
3
15.0%
暂无批准数据
- Children exposed to environmental tobacco smoke had a 67% higher arousal index than unexposed children, according to a prospective study using overnight polysomnography and urinary cotinine testing. - Higher urinary cotinine levels correlated with shorter total sleep time (r=−0.36) and lower sleep efficiency (r=−0.43), both reaching statistical significance. - Approximately 60% of smoking parents reported their child had no exposure, yet urinary cotinine confirmed actual exposure, highlighting a disconnect between parental perception and biological evidence. - Researchers emphasize that smoking outdoors or on balconies does not fully prevent exposure, as third-hand smoke residues persist on clothing, hair, and skin.
- Tel Aviv University researchers identified a previously unknown molecular mechanism driving ALS progression involving reduced microRNA-126 levels and toxic TDP-43 protein aggregates. - RNA-based gene therapy using microRNA-126 successfully stopped nerve cell degeneration and promoted regeneration in human cells and animal models. - The breakthrough findings reveal that muscle cells normally produce microRNA-126 to regulate TDP-43 protein expression at neuromuscular junctions. - This discovery could serve as the foundation for developing effective treatments for ALS, a fatal neurodegenerative disease affecting millions worldwide.
