Clinical Trials
285
26 active
Approvals
0
Total approvals
Agencies
0
Regulatory bodies
Founded
1764
Active, not recruiting
17
6.0%
Completed
184
64.6%
Enrolling By Invitation
3
1.1%
Not yet recruiting
6
2.1%
Recruiting
34
11.9%
Terminated
24
8.4%
Unknown
12
4.2%
Withdrawn
5
1.8%
No approval data available
- The National Institutes of Health has awarded a $26 million grant to Rhode Island's statewide clinical and translational research hub to fund its next five years of work. - The National Institute of General Medical Sciences issued the award on Sept. 3 to Brown University, the host institution for the Advance RI-CTR program. - Advance RI-CTR, launched in 2016, supports biomedical and public health scholars working to translate scientific discoveries into patient care improvements. - The program is a partnership spanning Brown University, the University of Rhode Island, Brown University Health, Care New England, the V.A. Providence Healthcare System and community organizations.
- Researchers at Brown University identified a linked set of genetic variants associated with decreased susceptibility to artemisinin, lumefantrine, and mefloquine in malaria parasites from Uganda. - The mutations, found in a gene encoding the PX1 phosphoinositide-binding protein, represent the first molecular marker correlated with reduced susceptibility to multiple drugs in combination therapy. - The findings, published in Nature Medicine, provide a tool for surveillance studies to track the emergence and spread of resistance to front-line malaria treatments across Africa. - Researchers emphasize the urgency of developing prediction models and new drugs as the rapidly spreading mutations threaten to undermine malaria control efforts.
- Florida Atlantic University, Brown University, and Florida International University received a five-year, $3.8 million NIH grant to develop new antimalarial drugs targeting the PfGARP protein. - The project builds on the discovery that antibodies against PfGARP trigger apoptosis in Plasmodium falciparum parasites within 12 to 24 hours, independent of other immune cells. - Researchers will use high-throughput screening to identify small molecules that mimic parasite-killing antibodies, creating a novel mechanism-based strategy to combat drug-resistant malaria. - Malaria caused approximately 263 million cases and nearly 600,000 deaths globally in 2023, with over 90% of fatalities occurring in sub-Saharan Africa and children under five disproportionately affected.
- A USC-led study of more than 214,000 older adults across 14 countries finds that modifiable dementia risk factors such as low education, high BMI, and hypertension vary dramatically by country, challenging one-size-fits-all prevention approaches. - Low education affected 85.6% of older adults in China versus only 12.0% in the United States, while high BMI was present in 44.9% of Americans compared to just 13.3% of Indians. - Despite country-level differences, cardiovascular risks like high cholesterol and hypertension clustered together globally, as did behavioral risks such as smoking and drinking, offering opportunities for bundled interventions. - The findings, presented at AAIC 2026 and published in The Lancet Healthy Longevity, suggest prevention programs should be tailored to local populations while leveraging consistent risk-factor clusters.
- A Brown University study finds that repeated adolescent cannabis use is associated with significantly lower tissue iron levels in dopamine-rich brain regions, suggesting disrupted dopamine system maturation. - The study of 81 teens aged 14–17 is the first to use MRI-based tissue iron measurement as a noninvasive marker of dopamine neurophysiology in adolescent cannabis users. - Higher-potency cannabis products and greater frequency of use showed more pronounced reductions in tissue iron, with daily concentrate hits and CUD severity both negatively associated with iron levels. - Researchers warn that altered dopamine development during this critical window may increase vulnerability to cannabis use disorder and future substance experimentation.
- Brown University researchers developed a smart hydrogel wound dressing that releases antibiotics only when harmful bacteria are detected through enzyme-responsive technology. - The system uses β-lactamase cleavable crosslinkers that degrade in bacterial presence, triggering ciprofloxacin-loaded liposome release while remaining intact without infection. - Preclinical studies showed complete bacterial eradication and enhanced wound healing in Pseudomonas aeruginosa infection models, outperforming commercial silver-based dressings. - The targeted delivery approach could reduce unnecessary antibiotic exposure and limit resistance development, addressing a major clinical challenge in wound care.
- Researchers at Brown University and Trisalus Life Sciences demonstrated that pressure-enabled drug delivery (PEDD) significantly enhanced nelitolimod distribution in liver tumors compared to conventional catheter delivery methods. - The PEDD system delivered nelitolimod with greater signal intensity and distribution in target tissue, resulting in significantly reduced tumor progression compared to systemic administration in preclinical models. - Treatment with PEDD-delivered nelitolimod promoted anti-tumor immunity by significantly reducing immunosuppressive myeloid-derived suppressor cells and increasing cytotoxic CD8+ T cells within liver metastases. - The findings suggest PEDD could overcome delivery challenges for liver tumors where direct injection is impractical due to lesion number, size, and location of target immune cells.
- Brown University researchers have developed peptide-decorated liposomes that specifically target Candida cells, dramatically increasing antifungal drug effectiveness while sparing healthy human cells. - The innovative approach uses penetratin peptides as molecular "homing devices" on liposomes containing posaconazole, inhibiting fungal growth at concentrations up to eight times lower and preventing biofilm formation at doses 1,300 times lower than conventional treatments. - In mouse models of Candida albicans infection, the targeted liposome delivery system reduced fungal burden by 60% compared to standard drug-loaded liposomes, offering new hope against increasingly drug-resistant fungal pathogens.
- New research reveals that more than 10.6 hours of daily sedentary behavior significantly increases risk of heart failure and cardiovascular mortality, even among those meeting exercise guidelines. - A complementary study from the University of Colorado demonstrates that prolonged sitting accelerates heart aging through negative impacts on cholesterol levels and BMI, with vigorous exercise only partially offsetting these effects. - Researchers recommend replacing sitting time with physical activity, using standing desks, and incorporating at least 30 minutes of vigorous daily exercise to mitigate cardiovascular risks.
- States enforcing abortion bans after the Dobbs decision experienced a 6% overall increase in infant mortality rates, resulting in 478 additional infant deaths compared to pre-ban projections. - Non-Hispanic Black infants were disproportionately affected with an 11% increase in mortality rates, highlighting significant racial disparities in the impact of abortion restrictions. - Texas showed the most dramatic impact with a 9.4% rise in infant deaths, while researchers noted an increase in births with fatal congenital anomalies in states where abortion was previously an option for such cases.
