University of Bath

Physicists at the University of Bath, using scanning tunnelling microscopy (STM), demonstrated control over competing chemical reaction outcomes in single molecules, potentially revolutionizing pharmaceutical research by improving reaction efficiency and reducing unwanted byproducts.

The BMJ investigation reveals extensive fossil fuel industry involvement in medical research, prompting calls for academics and publishers to cut ties. Over 180 articles acknowledged industry funding, and 1,000 featured authors linked to fossil fuel companies. Saudi Aramco and ExxonMobil were major contributors. Experts liken industry tactics to those of tobacco companies, urging journals to reconsider collaborations. The BMJ has extended its ban on fossil fuel-tied research and advertising.

Iterum Therapeutics' oral sulopenem faces FDA approval for uUTIs, with concerns over antibiotic resistance. The drug, a thiopenem antibiotic, previously faced rejection due to insufficient evidence. A Phase III trial showed efficacy in 61.7% of patients, leading to an NDA resubmission. The FDA's PDUFA date is October 25. The approval hinges on responsible use to prevent resistance.