UNIVERSITY OF MIAMI

ZYNLONTA in combination with rituximab shows 97% ORR and 77% CR rate in r/r follicular lymphoma, with 95% 12-month PFS. ZYNLONTA monotherapy in r/r marginal zone lymphoma shows 91% ORR and 70% CR.

Marcella Ali Kaddoura, MD, discusses an investigation into genomic determinants of clinical outcomes in t(11;14)-positive multiple myeloma patients treated with venetoclax, presented at the 2024 ASH Annual Meeting.

Tobacco smoking linked to specific genetic mutations in myelodysplastic syndromes (MDS), contributing to disease progression and survival reduction. Smoking cessation advised for newly diagnosed MDS patients to delay progression.

Smoking influences MDS pathogenesis through genetic mutations, with a dose-response relationship to disease progression and survival. Smoking cessation counseling is crucial for newly diagnosed MDS patients.

Tobacco smoking linked to specific genetic mutations in myelodysplastic syndromes (MDS), contributing to disease progression and lower survival rates. Smoking cessation advised to delay MDS progression.

Mission Bio collaborates with Dr. C. Ola Landgren to use Tapestri Single-cell DNA Multiple Myeloma Panel for MM relapse insights, aiming to improve patient outcomes and explore blood as an alternative to bone marrow samples.

The ReefLine project aims to transform Miami Beach's coastal waters with an underwater playland featuring a sculpture park, snorkel trail, and artificial reef. The first piece, Miami Reef Star, a 90-foot star sculpture, will be showcased during Art Basel Miami Beach. The project, funded by a $5m bond, involves marine biologists and uses eco-friendly materials like CarbonXinc and Coral Lok to benefit the environment. It is seen as a solution to climate change and a symbol of Miami's commitment to environmental leadership.

A review in *Health Science Reports* analyzes COVID-19 vaccine efficacy, safety, and complications in MS patients, finding reduced humoral response with anti-CD20 and S1P drugs, but intact T-cell responses. Severe COVID-19 outcomes are more common in patients on anti-CD20 therapies. Vaccination is safer than infection, with timing adjustments recommended for optimal efficacy, particularly a 12-week delay post anti-CD20 therapy. Side effects in MS patients mirror those in the general population, with rare severe cases noted in the AstraZeneca vaccine.

Genetic (WGS) and transcriptomic (snRNA-seq) data from 100 donors across multiple brain banks were collected, focusing on PD severity and control subjects. Data processing included nuclei isolation, snRNA-seq library preparation, and computational analysis to align reads, demultiplex samples, and cluster cells. WGS data underwent library preparation, alignment, variant calling, and ancestry estimation using QDA.

Dr. Victor Hugo Hernandez, M.D., joins The Hip Society, an elite organization recognizing orthopaedic surgeons and researchers improving hip care. The society, limited to 100 members, requires rigorous qualifications, including 100 hip surgeries annually and 10 high-impact publications. Dr. Hernandez focuses on glucose control in surgery and uses augmented reality for precision. He aims to contribute to research and education, sharing knowledge with colleagues and trainees.