Kantonsspital Winterthur

Malignant Serous Effusions Offer Molecular Insights for Precision Oncology

8 months ago

• A prospective study analyzed malignant serous effusions (MSEs) from 184 patients to understand the molecular landscape and drug responses for precision oncology. • The study integrated genomic, transcriptomic, and proteomic data from MSEs to identify potential therapeutic targets and predict drug sensitivities. • Ex vivo drug screening (pharmacoscopy) was performed on MSE-derived cells to quantify cellular composition and drug responses, revealing personalized therapeutic strategies. • Multi-omics factor analysis identified disease-specific factors and potential therapeutic targets, offering insights into patient-specific drug responses.