Tampa General Hospital (TGH) Cancer Institute, approaching its 3-year anniversary, has achieved significant progress through innovative solutions, including a 3-year COC accreditation, Newsweek's top cancer hospital recognition, and the TGH-USF Health Precision Medicine Biorepository. The institute has recruited 22 physicians and 20 advanced practice providers, and integrated CareComm for improved patient care, reducing inefficiencies by $40 million. TGH has also expanded its radiation oncology program with new technologies like CyberKnife and TrueBeam, aiming for NCI designation within the decade.